Upon testing Imipramine, it was found to yield a significant antidepressant response among depressed individuals.
This lead to a trend of many companies developing tricyclic antidepressants with different three ring structures from Imipramine.
Although some TCAs tend to affect serotonin and norepinephrine equally, some affect one to a significantly greater extent.
Additionally there are others that don’t affect either neurotransmitter to a significant extent; these are listed as “atypical” TCAs.
This drug works primarily as a serotonin-norepinephrine reuptake inhibitor, favoring the serotonin reuptake inhibition slightly more than that of norepinephrine.
There is even some evidence suggesting that this TCA may be more effective than SSRI antidepressants.
It is on the World Health Organization’s List of Essential Medicines due to its efficacy as a TCA.
I later found that amitriptyline’s quite toxic, can put you in a coma. I took my overdose then changed from amitriptyline to Cipramil.
If I’d had that pack of amitriptyline I would probably have been in a coma, possibly dead, I don’t know. But these tricyclics, the cheaper ones which tend to be prescribed more often, because they are cheap and they’re older, are quite toxic.
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Below is a list of TCAs that affect serotonin and norepinephrine to a similar extent.
Although most affect one neurotransmitter slightly more than the other, differences are considered minimal.There are many reasons why a cookie could not be set correctly.